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Tretinoin: The Only FDA‑Approved Cream for Fine Wrinkles & Sun Damage. You’ve probably used “retinol” for years… but that’s not the same thing as prescription retinoic acid (tretinoin). Tretinoin is the prescription‑strength form that’s actually FDA‑approved to treat fine facial wrinkles, mottled hyperpigmentation (sun spots), and skin roughness from photodamage. It is powerful, which means you have to introduce it slowly, buffer if needed, and protect your barrier so you get the collagen and pi
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