Should we be concerned about Brock Purdy? Could the Titans and Browns pull off upsets? And is Trevor Lawrence startable in fantasy in

When you looked at the 49ers’ schedule back in August, you probably circled this Week 13 trip to Cleveland as an easy road win. The Browns stink. They always stink. It’s part of the NFL’s natural order, like the sun rising or Tom Brady botching the broadcast call on a big third down.

The San Francisco 49ers overcame that Thanksgiving Week generosity and toppled the Carolina Panthers 20-9, thanks largely to defensive heroics that included two interceptions by safety Ji’Ayir Brown.

Brandon Aiyuk in this 2026 NFL mock draft with Louisville's Chris Bell, plus key picks on defense and offensive line.

Thanks in large part to a stellar defense and a workhorse performance by Christian McCaffrey, the 49ers were able to overcome a bad night by Brock Purdy to defeat Bryce Young and the Panthers on Monday night.

Everything you need to know about the NFL match between Cleveland Browns and San Francisco 49ers, as well as kick-off time and team news

NFL Week 12 odds, picks, predictions, TV channel, streaming information for Monday Night Football between Carolina Panthers and San Francisco 49ers.

Is Brandon Aiyuk done in San Francisco? Jay Glazer shared why the wide receiver is on thin ice with the 49ers.

Panthers safety Tre'Von Moehrig is suspended for one game following an altercation with 49ers wide receiver Jauan Jennings.