The Arizona Cardinals were not the NFL's most talented team during the second year of coach Jonathan Gannon's tenure, but they were among the most disciplined, committing the league's second-fewest penalties in 2024.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

Setting NFL records is cool - but winning is much cooler in the eyes of Arizona Cardinals QB Jacoby Brissett. In the process of being routed by the San Francisco 49ers in Week 11, Brissett set an NFL record with 47 pass completions today. Brissett, when speaking with reporters after the loss, says he couldn't care less.

The rookie fourth-rounder was busy in the second start of his NFL career, leading the Cardinals with 12 stops. With Mack Wilson (ribs) placed on injured reserve prior to Sunday's contest, Simon should serve as the Cardinals' starting middle linebacker for at least the next three games and for as long as the former is on IR.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

Cardinals 2026 NFL Draft mock: Every pick, potential starters, and the moves that could reshape the team. The season feels all but over for the Arizona Cardinals, and fans are ready for the offseason.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

Dallas looks to snap its two-game losing streak against struggling Las Vegas at Allegiant Stadium, with kickoff set for 8:15 p.m. ET on ABC/ESPN. Here's how to watch for free.

Christian McCaffrey National Football League San Francisco 49ers Top Plays NFL - San Francisco 49ers vs. Arizona Cardinals - 11/16/2025