Recently disclosed longer-term REVEAL Part A data demonstrated broad, multi-domain functional impact that deepened over time through ≥12 months post-TSHA-102 regardless of age or disease severity ...

Learn how viral vector release testing for AAV and lentiviral vectors utilizes orthogonal assays for titer, capsid content, ...

BOSTON — A team at Children’s Hospital of Philadelphia (CHOP) led by Rebecca Ahrens-Niklas, MD, PhD, and Lindsey George, MD, has described a case of a brain tumor linked to a rare integration of adeno ...

Recombinant adeno-associated virus (AAV) vectors are predominantly nonintegrating, but rare genomic integration events have been associated with oncogenesis in neonatal murine models. Here we report a ...

While there is no cure for ANCA-associated vasculitis (AAV), treatment is usually very effective at bringing it under control and preventing life-threatening complications. This group of rare ...

Scientists from the Gray Faculty of Medical & Health Sciences at Tel Aviv University introduced an innovative gene therapy method to treat impairments in hearing and balance caused by inner ear ...

Biogen joins the likes of Roche, Takeda and Vertex Pharmaceuticals, companies that have all recently shed work in AAV capsid development. (iStock/Getty Images Plus) Biogen has discontinued all gene ...

Scientists have a new trick to tackle TDP-43: antibodies delivered via adeno-associated virus. In the September 3 Molecular Therapy, scientists led by Damien Nevoltris at AC Immune, Lausanne, ...

Scientists have a problem studying self-love. Research abounds on self-compassion, self-esteem, self-care, and even unconditional positive self-regard. Scholars have published definitions of these ...

· Longer genomes result in lower AAV yield and reduced bioactivity. · Small genomes (2.0–2.25 kb) are prone to “over-packaging,” leading to the formation of self-complementary AAVs (scAAVs). · Large ...

Lively discussions have sprung up here in editor Aalyia Shaukat’s Design Ideas regarding the limitations and quirks of, and design tricks for, the current control topologies shown in Figure 1. Figure ...