A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the ...

Proteomics is the study and analysis of proteins, including their structures, functions, interactions, and modifications within a biological system. Humans have approximately 20,000 genes that produce ...

Joshua C. Snyder is in the Departments of Surgery and Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA. Marti-Solano and colleagues set out to determine how the ...

What happens if a protein-based biotherapeutic includes unexpected isoforms? Traditional, analysis might not even reveal very similar isoforms in a biotherapeutic. So, Jonathan Bones, PhD, principal ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

Researchers have discovered a blood signature of protein isoforms that could potentially predict which patients may reject a new organ transplant, helping inform therapeutic decisions. The findings of ...

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered ...

During the last decade, several novel members of the Epidermal Growth Factor family of peptide growth factors have been identified. Most prominent among these are the Neuregulins or Heregulins. To ...