When TDP-43 escapes from the nucleus, cells bungle mRNA processing, chopping up and splicing transcripts in the wrong places. Most studies have focused on retention of “cryptic” exons, but recent work ...
Inflammation is known to contribute to Alzheimer’s disease progression, fueling the buildup of tau and amyloid pathology, and yet epidemiology suggests that people with the chronic inflammatory ...
A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.
A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...
12 &#x2013 14 January 2026 DOWNLOAD TO YOUR CALENDAR San Juan, Puerto Rico View Conference Website ...
The center currently accepts only fresh brain donations from the general population, and does not bank Alzheimer's brains or brains with unspecified dementia. Normal controls are welcome, as are ...
Perlman Neurology Outpatient Clinic 8950 Villa La Jolla Drive Suite C129 La Jolla, CA92037 United States Visit Website Contact: Douglas Galasko, M.D Phone: 858-657-8540 E-mail: [email protected] ...
Amyloid immunotherapies are here, but inflammaging remains a powerful driver of neurodegenerative disease. Neuroinflammation is a rich, but thus far quite elusive, source of new drug targets. Some ...
More than two decades have passed since William Pardridge of the University of California, Los Angeles, used the analogy of a Trojan horse to describe molecular transport shuttles that can sneak ...
In a small, open-label trial in people with mild to moderate, dominantly inherited Alzheimer’s disease (DIAD), the tau immunotherapy etalanetug almost abolished markers of neurofibrillary tangles in ...
APOE4 was originally studied in the context of blood lipids and cardiovascular disease and first characterized at the protein level as one of three inherited ApoE isoforms with unique ...
Despite Phase 2 Strike-Out, New Tau Antibodies Step Up to Plate Add To My AlzForum 23 Dec 2025 first-in-human studies of three tau antibodies— all aiming to stop seeded tau propagation in its ...