IL-11 leads to fat accumulation and muscle mass loss, two key hallmarks of aging. In preclinical studies, the team found that with age, organs expressed increasing levels of the IL-11 protein ...

Alphabet-founded biotech Calico Life Sciences has struck an exclusive licensing agreement with Chinese drugmaker Mabwell (SHA ...

Lassen Therapeutics, a clinical stage biotech company developing first-in-class antibody therapeutics targeting interleukin-11 receptor (IL-11R, LASN0 ...

A research group led by Prof. Hiroyasu Nakano of Department of Biochemistry, Toho University Faculty of Medicine, found that interleukin 11 (IL-11)-positive cells rapidly appear in the colons of ...

Inhibition of IL-11 signaling also showed a significant anti-fibrotic effect in the lung and skin in animal models of fibrosis. More information on the Phase 1 study ( NCT05331300 ) is available ...

Interleukin (IL)-11 is produced by inflammatory fibroblasts, one of the stromal cells, during acute colitis. Researchers at Toho University Japan found that IL-11 ameliorated acute colitis in ...

Three strains of mice were used for the animal model experiments — mice with deleted interleukin 11 receptor subunit alpha 1 (IL11RA1) gene, mice with deleted IL11 gene, and mice with the gene ...

Interleukin-11 (IL-11) is an interesting and unique pleiotropic cytokine, originally characterized as a hematopoietic cytokine with thrombopoietic activity. Yet recently, IL-11 has been implicated ...

Persons would receive a single dose of RNAi that, like monthlong depot injections of some FDA permitted medications, causes the RNAi to cumulatively epigenetically downregulate the interleukin-11 ...

Scientists have found an unlikely anti-aging drug in the form of an anti-inflammatory drug that is designed to inhibit an ...

Scientists have found an unlikely anti-aging drug in the form of an anti-inflammatory drug that is designed to inhibit an inflammatory molecule known as interleukin-11 (IL-11).