IL-11 leads to fat accumulation and muscle mass loss, two key hallmarks of aging. In preclinical studies, the team found that with age, organs expressed increasing levels of the IL-11 protein ...

A research group led by Prof. Hiroyasu Nakano of Department of Biochemistry, Toho University Faculty of Medicine, found that interleukin 11 (IL-11)-positive cells rapidly appear in the colons of ...

Inhibition of IL-11 signaling also showed a significant anti-fibrotic effect in the lung and skin in animal models of fibrosis. More information on the Phase 1 study ( NCT05331300 ) is available ...

Interleukin (IL)-11 is produced by inflammatory fibroblasts, one of the stromal cells, during acute colitis. Researchers at Toho University Japan found that IL-11 ameliorated acute colitis in ...

A poster entitled “LASN01, a high affinity anti-interleukin-11 receptor antibody, blocks pathological mechanisms of thyroid eye disease linked to clinical efficacy” described how LASN01 ...

Persons would receive a single dose of RNAi that, like monthlong depot injections of some FDA permitted medications, causes the RNAi to cumulatively epigenetically downregulate the interleukin-11 ...

This is a visual abstract/ illustration of 'Interleukin 11 is a crucial determinant of cardiovascular fibrosis' published in Nature. "Fibrotic diseases represent a major cause of illness and death ...

Scientists have found an unlikely anti-aging drug in the form of an anti-inflammatory drug that is designed to inhibit an ...

Jan. 29, 2003 — Recombinant human interleukin 11 (IL-11) reduces the frequency and load of bacteremia associated with chemotherapy, according to the results of a randomized, double-blind ...

PURPOSE: Interleukin-11 (IL-11) is a thrombopoietic cytokine that attenuates postchemotherapy thrombocytopenia at doses of 50 μg/kg/d subcutaneously. Very little is known about the activity of IL-11 ...