Hypoxia, or low oxygen in the body, is common in solid tumors. Now, researchers have identified that an RNA molecule, EUDAL, ...
The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become ...
EGFR is tagged by c-Cbl/Grb2 for breakdown inside lysosomes. In hypoxia (right), the RNA molecule EUDAL prevents this process, keeping EGFR permanently active. This activates the STAT3/BNIP3 pathway, ...
New insights to gene expression signatures from primary FFPE tumors for the prediction of response to cetuximab in KRAS and BRAF wild-type colorectal cancer (CRC). Background: KRAS mutated CRC ...
Conclusions: Lack of phosphorylation of AKT and lack of PTEN expression in the AKT pathway downstream of EGFR may be a mechanism of MPM's clinical resistance to OSI-774. ERK is variably activated ...
Please provide your email address to receive an email when new articles are posted on . A number of epidermal growth factor receptor inhibitors used in the oncology setting continue to demonstrate ...
The RAMOSE and RELAY trials revealed the capacity and constraints of combination therapy with ramucirumab (Cyramza) in EGFR-mutated metastatic non-small cell lung cancer (NSCLC). The phase II RAMOSE ...
Treating constipation with lubiprostone may confer renal benefits in chronic kidney disease by modulating microbiome-driven ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback