A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the ...

Proteomics is the study and analysis of proteins, including their structures, functions, interactions, and modifications within a biological system. Humans have approximately 20,000 genes that produce ...

Joshua C. Snyder is in the Departments of Surgery and Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA. Marti-Solano and colleagues set out to determine how the ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

What happens if a protein-based biotherapeutic includes unexpected isoforms? Traditional, analysis might not even reveal very similar isoforms in a biotherapeutic. So, Jonathan Bones, PhD, principal ...

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors. The ...

Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered ...

Correspondence to: Dr B C Nindl Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, MA 1760, USA; bradley.nindl{at}na.amedd.army.mil If you wish to reuse any ...