A novel compound that inhibits the BAF chromatin remodeling complex causes regression in an animal model of the incurable cancer uveal melanoma.
The serine 31 (Ser31) phosphorylation modification (H3.3S31ph) in the N-terminal tail of the histone variant H3.3 can ...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide, largely due to the limited efficacy of ...
Depression affects millions worldwide, yet its root cause has long remained elusive. Behind its lived experience lies a biological mystery: Why does the brain, an organ built to adapt and survive, ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In the presence of chromatin bridges in ...
This interesting study presents important information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations ...
A substantial amount of castration-resistant prostate cancer (CRPC) progresses into a neuroendocrine (NE) subtype, known as NEPC, which is associated with poor clinical outcomes. Here we report ...
School of Life Sciences, The Chinese University of Hong Kong, Sha Tin, N.T., Hong Kong, 999077 State Key Laboratory of Agrobiotechnology, and School of Life Sciences, The Chinese University of Hong ...
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