Abstract: Nucleic acid sequences rich in guanine (G) bases tend to form non-canonical structures called G-quadruplex (G4). G4s hold promise in the treatment of many diseases, including cancer, so ...
An unusual DNA structure may hold the key to treating one of the deadliest cancers affecting women, which claims more than 200,000 lives globally each year. Most women with ovarian cancer respond very ...
Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...
Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...
Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...
RNA transcription is the genomic process in which a cell produces a duplicate of a gene’s DNA sequence. Present in both DNA and RNA sequences, a G-quadruplex (GQ) is a structure of four guanine bases ...
Overexpression of the receptor tyrosine kinase PDGFR-β promotes cancer growth and metastasis. PDGFR-β is a validated cancer target but PDGFR-β kinase inhibitors suffer from lack of selectivity and ...
A new research paper was published in Oncotarget entitled, "G-quadruplex landscape and its regulation revealed by a new antibody capture method." In this new study, researchers Subhamoy Datta, Manthan ...
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