Chemical structure for thiamine pyrophosphate and protein structure of transketolase. Thiamine pyrophosphate cofactor in yellow and xylulose 5-phosphate substrate in black. Credit: Thomas ...

Researchers participating in the Enzyme Function Initiative (EFI) have used a computationally rich metabolite-docking strategy to sift through a protein’s potential metabolic partners and predict its ...

COLLEGE STATION, Nov. 6, 2007 – Fitting a key into a lock may seem like a simple task, but researchers at Texas A&M University are using a method that involves testing thousands of keys to unlock the ...

Study in fission yeast revealed a key role for a set of enzymes called agmatinases, which break down the metabolite agmatine into polyamines.

Enzymes are substances in the body that cause and speed up crucial chemical reactions. Enzymes’ function is to help trigger ...

Annotations of enzyme function provide critical starting points for generating and testing biological hypotheses, but the quality of functional annotations is hindered by uncertain assignments for ...

Researchers from Queen Mary University of London's School of Biological and Behavioral Sciences, using the simple fission ...

Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with ...

Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation.

The function of the glycolytic enzyme hexokinase 1 differs depending on its location within the cell, according to a Northwestern Medicine study published in Molecular Cell. The enzyme uses different ...

Researchers at Baylor College of Medicine and collaborating institutions report in the journal Nature Communications how a mutation in the enzyme SKD3 can cause a form of a genetic disease known as ...