The deubiquitinase USP17LA negatively regulates T-cell activation and attenuates anti-tumor immunity
USP17LA loss enhances T-cell function and anti-tumor activity in murine tumor models. Usp17la-deficient T cells exhibit ...
This valuable study examines the cleavage of motor neuron nucleoporins by proteases 2A and 3C of enterovirus D68, a pathogen associated with acute flaccid myelitis. The evidence supporting the effects ...
11hon MSN
Scientists reveal functional RNA splitting mechanism behind origin of type V CRISPR systems
CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR ...
New research shows fat buildup disables brain’s immune defenses in Alzheimer’s. A mouse treatment cleared plaques in just one week.
The locomotor system, encompassing bones, joints, and soft tissues, is essential for movement and stability, relying on finely tuned immune and inflammatory ...
It is now well accepted that cells of the nervous and immune systems communicate through bidirectional signaling mediated by the release of cytokines, ...
Objectives Gout is a common disease causing excruciatingly painful and disabling flares. Although currently approved treatments for gout flares are generally effective, their use is restricted in many ...
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