Preoptic neurotensinergic neurons co-release GABA and neurotensin, triggering a rapid initial inhibition followed by a sustained excitation, and mice lacking GABA release from these neurons exhibit ...

A biophysical approach sheds light on the electron transport physics and electric metabolism of centimeter-long filamentous freshwater cable bacteria.

The chemokine CCL28 is highly expressed in mucosal tissues, but its role during infection is not well understood. Here we show that CCL28 promotes neutrophil accumulation in the gut of mice infected ...

Slow and fast movements are controlled by distinct sets of spinal V2a neurons with matching properties and connections.

Zebrafish (AB strain) were raised at 28 °C in a ZebTEC system. The photoperiod was 14 h of light and 10 h of darkness. Zebrafish were fed with artemia twice a day. The experiments in this study were ...

Neuroscience Institute, Carnegie Mellon University, Pittsburgh, USA ...

This important study reports the molecular function of the SARS-CoV-2 helicase NSP13, which inhibits the transcriptional activity of the YAP/TEAD complex in vitro and in vivo. The evidence supporting ...

The larval zebrafish is a vertebrate model for in vivo monitoring and manipulation of whole-brain neuronal activities. Tracing its neural circuits still remains challenging. Here we report an ...

To test if somatic mutations in cancer genomes are enriched with mutations in polyadenylation signal regions, the authors observed an increased enrichment of somatic mutations that may affect the ...

Regeneration of sensory axons after a burn injury depends on early keratinocyte responses regulated by the wound microenvironment.

Photopharmacological manipulations of mGlu5 receptors with light-sensitive negative allosteric modulators show brain region-specific roles in pain modulation and suggest that blockade of mGlu5 ...

The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.