Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases. PLS typically develops slowly, while ALS rapidly affects mobility and can become fatal.

Henry P, a 78-year-old white man, presents for evaluation because he recently fell while crossing the street. He states that he lost his balance on a windy day but is not sure what caused him to fall.

Degenerative cervical myelopathy (DCM) is a clinical condition of upper motor neuron lesion signs, that is confirmed with advanced imaging demonstrating compression of the spinal cord in the cervical ...

Northwestern University scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic ...

A diagnosis of amyotrophic lateral sclerosis can be overlooked by clinicians unfamiliar with the various signs of the disease. ALS is purely a motor neuron disease; sensory neurons are not affected. 4 ...