DNA-binding proteins from volcanic lakes could improve disease diagnosis

Scientists have uncovered new DNA-binding proteins from some of the most extreme environments on Earth and shown that they ...
Kaleido Scope

Simplified redesign of proteins to improve ligand binding

Various approaches to such protein redesign have drawbacks. Traditional methods include time-consuming trial and error efforts, and many models in the emerging field ...
Durham University

Scientists discover new DNA-binding proteins from extreme environments that could improve disease diagnosis

One of the new DNA-binding proteins was tested in a medical diagnostic method known as loop-mediated isothermal amplification ...
Chromatography Online

Mass Spectrometry–Driven Strategies for Membrane Protein–Targeted Drug Discovery

Membrane proteins are vital for cellular signaling, transport, and communication, making them attractive drug targets despite their challenging properties. Advances in mass spectrometry have enabled ...
Science Daily

A deep learning pipeline for controlling protein interactions

Scientists have used deep learning to design new proteins that bind to complexes involving other small molecules like hormones or drugs, opening up a world of possibilities in the computational design ...
EurekAlert!

Expanding the sequence spaces of synthetic binding protein using deep learning-based framework ProteinMPNN

Protein design is crucial for the treatment of human diseases, but traditional protein design methods have some limitations. Site-directed mutagenesis is highly dependent on the physiological ...
News Medical

Dysregulation of RNA-binding proteins in rheumatoid arthritis and osteoarthritis

Announcing a new publication for Acta Materia Medica journal. Single-cell RNA sequencing (scRNA-seq) data from published datasets were obtained to investigate the expression and dysregulation of ...