Selective ASO-based JAK2 inhibitor for the treatment of hematological malignancies with JAK2 V617F mutation burden. Use of causal modeling to uncover cell-cell communication dynamics in the tumor ...
Apoptosis signal-regulating kinase 1 (ASK1) is a pivotal mediator in cellular stress responses, particularly in pathways leading to programmed cell death or apoptosis. ASK1’s activation under ...
Cells that are about to die send a signal to an executioner protein, but sometimes, those cells can fight back and regenerate ...
Aligos Therapeutics Inc. has disclosed programmed cell death 1 (PDCD1; PD-1; CD279) and/or PD-1 ligand 1 (PD-L1; CD274) and/or PD-1/PD-L1 interaction inhibitors reported to be useful for the treatment ...
In an extensive review, researchers explore ZBP1-mediated programmed cell death and its potential as a therapeutic target for systemic diseases Programmed cell death, or PCD, is an actively regulated ...
In the fight against disease, programmed cell death – also known as apoptosis – is a key protective function of the body. It breaks down cells that are damaged or have undergone dangerous changes.
A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...
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Researchers explore the connection between programmed cell death and tissue regeneration
The delicate balance between cell death and regeneration is crucial for human health and longevity. Most mechanisms involved in programmed cell death (PCD) play a key role in normal tissue renewal and ...
This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...
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