In a paper published on March 28 in Sciencexpress, Rachel Brem and colleagues describe how linkage analysis and gene expression profiling can be combined to dissect transcriptional regulatory networks ...

Introduction: Families of admixed ancestry are routinely excluded from traditional linkage analysis (LOD score) or are analyzed as deriving from a homogeneous population of the proband's ethnicity.

Preliminary work has suggested linkage of the Nettleship-Falls type of X-linked ocular albinism (XLOA) with three anonymous loci DXS85, DXS16, and DXS9; respectively defined by probes p782/EcoRI ...