Degenerative aortic stenosis (AS) has become the most common valvular heart disease and the definitive treatment of symptomatic, severe AS is surgical valve replacement. In the absence of symptoms, ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

It is a common perception that approximately 50% of heart failure (HF) patients present with a normal or near-normal left ventricular (LV) ejection fraction ("HF with preserved systolic function"), ...

Ejection fraction is a measurement doctors can use to help diagnose heart failure. A normal range is between 52% and 72% for males and between 54% and 74% for females. An ejection fraction that’s ...

Avoiding Peg-Filgrastim Prophylaxis During the Paclitaxel Portion of the Dose-Dense Doxorubicin-Cyclophosphamide and Paclitaxel Regimen: A Prospective Study Dexrazoxane use should be considered during ...

End-diastolic volume is the amount of blood that is in the ventricles before the heart contracts. Doctors use end-diastolic volume to estimate the heart’s preload volume and to calculate stroke volume ...

Background: Prolonged steady state exercise can lead to a decrease in left ventricular (LV) function as well as promote the release of cardiac troponin T (cTnT). There is limited information on the ...

Chronic heart failure is a syndrome, not a specific disease, and occurs as a final common pathway in multiple disease states. The pathophysiology of chronic heart failure (HF) exists when either the ...

Medically reviewed by Christopher Lee, MD Systolic congestive heart failure involves the left side of your heart losing its ability to pump effectively.Common symptoms include shortness of breath, ...

The benefit of an implantable cardioverter–defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for ...

Objective: To provide an overview of heart failure with preserved ejection fraction (HFPEF), as well as its pathophysiology, diagnosis, and clinical evidence regarding its pharmacologic management.