Nature

A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis

Figure 1: Cervimycin structures and results of knocking out CerJ. A BLAST search for sequence-similar proteins with CerJ yielded sequences of proteins that have not yet been biochemically ...
ascopubs.org

Update on phase 1 study of tazemetostat, an enhancer of zeste homolog 2 inhibitor, in pediatric patients with relapsed or refractory integrase interactor 1–negative tumors.

Predicting outcomes with circulating adrenergic neuroblastoma mRNAs in children with relapsed and refractory neuroblastoma: A BEACON-Neuroblastoma biomarker study. Phase I trial of lorlatinib in ...
ascopubs.org

Phase 1/2 first-in-human (FIH) study of CPI-0209, a novel small molecule inhibitor of enhancer of zeste homolog 2 (EZH2) in patients with advanced tumors.

A phase Ib trial of ERK inhibition with ulixertinib combined with palbociclib in patients (Pts) with advanced solid tumors. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This ...
GEN

Fly Homolog of Human Exercise Protein Precursor Regulates Cold Tolerance, Cellular Maintenance

Researchers at University of Michigan (U-M) Medical School and Wayne State University School of Medicine have identified, in fruit flies, a protein that, when missing, makes exercising in the cold ...
Science Daily

Homolog of mammalian neocortex found in bird brain

Most higher-order processing by the human and mammalian brain is thought to occur in the neocortex, a structure on the surface of the brain. Now researchers have found cells similar to those of the ...
Science Daily

Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows its promise for gene editing

Scientists have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in biomedicine is currently underway, driven ...
JSTOR Daily

MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor

N⁶-Methyladenosine is a ubiquitous modification identified in the mRNA of numerous eukaryotes, where it is present within both coding and noncoding regions. However, this base modification does not ...
Healio

BRAF: v-raf murine sarcoma viral oncogene homolog B

FDA-Approved Targeted Therapy: Dabrafenib plus trametinib (Novartis): This BRAF + MEK combination therapy was granted full approval by the FDA in 2017 and is the only approved treatment for patients ...
JSTOR Daily

TERMINAL FLOWER2, an Arabidopsis Homolog of HETEROCHROMATIN PROTEIN1, Counteracts the Activation of FLOWERING LOCUS T by CONSTANS in the Vascular Tissues of Leaves to ...

The Plant Cell, Vol. 15, No. 12 (Dec., 2003), pp. 2856-2865 (10 pages) The flowering time of plants is tightly regulated by both promotive and repressive factors. Molecular genetic studies using ...

Amphista Therapeutics discloses first details of its SMARCA2 degrader program

Structurally-guided discovery using high-resolution cryo-EM has delivered potent, DCAF16-dependent Targeted Glues™ of SMARCA2, with exquisite ...
Hosted on MSN

Structure of a eukaryotic CRISPR-Cas homolog, Fanzor2, shows promise for gene editing

Scientists at St. Jude Children's Research Hospital have revealed how Fanzor2's divergence from bacterial ancestors may make it a useful tool for future genomic engineering endeavors. A revolution in ...