G-quadruplexes are non-canonical secondary structures formed by guanine-rich sequences in DNA and RNA. Four guanines assemble into a planar tetrad through Hoogsteen hydrogen bonding, and stacked ...

A collaboration led by Distinguished Professor Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology (TUAT), Japan, discovered that G-quadruplex (G4)-forming DNA binds myoglobin ...

DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod ...

DNA, the genetic material compacted in chromosomes, stores information to regulate all the cell processes in the body. Two decades ago, in addition to the widely known Watson-Crick double helix model ...

As an important non-canonical DNA secondary structure in vivo and in vitro, G-quadruplexes (GQs) have been widely investigated in many fields including biology, medicinal chemistry, supramolecular ...

Guanine quadruplexes (G-quadruplexes or G4s) are unusual nucleic acid structures with distinct biological and chemical functions. They have occupied significant attention in the nucleic acid world ...

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can play ...

Not all DNA looks like the familiar double helix. Sometimes, parts of our genetic code fold into unusual shapes under certain conditions. One such structure known as a G-quadruplex (G4) looks like a ...

Get unlimited access to ad-free articles and exclusive content. Sixty years after scientists described the chemical code of life — an interweaving double helix called DNA — researchers have found four ...