RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I ...
A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA. Published online May 16 in the journal Cell, the report describes the ...
As expected, accuracy also depended on whether the DNA polymerase retains a 'proofreading' functionality, which verifies (and if necessary removes) any mismatched nucleotides: a version of the enzyme ...
The latest short science news items from C&EN. Ting F. Zhu, who led the work, says it is a step on the way to creating a mirror version of the so-called central dogma of molecular biology, which ...
Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 15 (Jul. 17, 2001), pp. 8376-8380 (5 pages) The β and proliferating cell nuclear antigen (PCNA) sliding ...
A common hallmark of viral genome replication is a high mutation rate, which can aid in their ability to evade new treatments and acquire resistance to once-effective antiviral medications. Now, a new ...
Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study The DNA damage response (DDR) ...
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