Persistent Doubts about Reproducibility and Compatability of Data Are Being Overcome One of the hottest research tools these days within the academic, biotech, and pharma communities is DNA ...

In each type of cell, like a muscle cell or a skin cell, different genes are expressed (turned on) or silenced (turned off). If the cells that are turned on mutate, they could—depending on what role ...

A new method for reading DNA (or RNA) microarrays is based on measuring the electrostatic repulsion between silica microspheres and hybridized DNA. Surface areas containing double-stranded DNA (red) ...

Students model how scientists use DNA microarrays to determine levels of gene expression in breast cancer patients, and then choose treatments based on what they learn. Normal-functioning DNA codes ...

Most pharmaceuticals sold today have their origin in a biochemistry laboratory. Drug discovery has traditionally started with a biochemical pathway implicated in a pathophysiological process. An ...

DNA microarray chips enable the parallel investigation of a given sample concerning the presence and amount of specific DNA sequences within that sample. Whereas today such chips utilize optical ...

BUFFALO, N.Y. -- A multidisciplinary team of pharmaceutics and computer-science researchers at the University at Buffalo, one of very few teams in the nation applying DNA microarray technology in ...

In 1997, Juha Kononen, a postdoctoral fellow at the National Human Genome Research Institute, was pondering the significance of the recently developed DNA microarray. He was studying genetically ...

Gene amplifications and deletions frequently have pathogenetic roles in cancer. 30,000 radiation-hybrid mapped cDNAs provide a genomic resource to map these lesions with high resolution. We developed ...

Processes Involved in Using DNA Microarray Instrumentation in Protein Microarray Workflow Protein microarrays offer the ability to measure protein expression and antibody binding in a high-throughput ...

BERKELEY, CA — The dream of personalized medicine — in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile — may be on the verge of being expanded ...