Picture in your mind a traditional “landline” telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...
DNA gyrase, a bacterial type II topoisomerase, is instrumental in maintaining DNA supercoiling during replication and transcription. Owing to its absence in higher eukaryotes, it represents an ...
Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...
DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrasetargeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a ...
Scientists uncover new mechanism in bacterial DNA enzyme opening pathways for antibiotic development
Researchers from Durham University, Jagiellonian University (Poland) and the John Innes Centre have achieved a breakthrough in understanding DNA gyrase, a vital bacterial enzyme and key antibiotic ...
Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone. The coiled telephone cord and the DNA double helix that stores the genetic material in ...
Researchers reveal how DNA gyrase resolves DNA entanglements. The findings not only provide novel insights into this fundamental biological mechanism but also have potential practical applications.
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