When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

Given the remarkable advances seen with gene therapies for sickle cell disease (SCD), it may seem counterintuitive to suggest the space may be in need of more therapies that have already been ...

Scientists have created a new compound that can self-destruct cancer cells. The compound is made up of two proteins, which researchers "glued" together. They describe the process in a paper published ...

The story of the princess and the pea evokes an image of a highly sensitive young royal woman so refined, she can sense a pea under a stack of mattresses. When it comes to human biology, it also takes ...

For years, chimeric antigen receptor (CAR) T cell therapies have led the way in cell-based immunotherapy, offering hope to many patients with certain blood cancers. But now, researchers believe the ...

With their unique ability to self-renew and differentiate into specific cell types, stem cells have already left an indelible mark on medicine, but researchers have only scratched the surface of their ...

Extracellular vesicles and particles are central to how cells communicate, especially in cancer, where they help shape metastasis and treatment resistance. However, most existing methods analyze ...

Not all patients respond well to chimeric antigen receptor (CAR) T cell therapies, which reprogram a patient’s own immune cells to recognize and attack cancer. A way to optimize these treatments is to ...

In A Nutshell As cells age, they deliberately shrink a major internal structure called the endoplasmic reticulum. This downsizing happens early in adulthood and shifts cells away from protein ...