Optimal timing and dosing of adjuvant cyclin-dependent kinase (CDK) 4/6 inhibitor in early breast cancer is controversial. This prospective phase II clinical trial investigated tolerability and safety ...

Neoadjuvant immunotherapy for patients with resectable stage III/IV cutaneous melanoma: A Swedish retrospective real-world study (NEO-MEL). This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...

Adjuvants alone are not licensed; a specific adjuvant/antigen formulation is licensed. This implies that the development of an adjuvant is strictly related to the antigen present in the specific ...

A sweeping BMJ review of nearly a century of human evidence finds no causal signal linking aluminum-adjuvanted vaccines to serious systemic disease, while confirming that rare local nodules remain the ...

Programmable nucleic acid nanoparticles boost vaccine immune responses as effectively as standard adjuvants in mice while avoiding the autoimmune risks that limit existing alternatives. (Nanowerk ...

Adjuvants play a crucial role in enhancing vaccine efficacy. Although several adjuvants have been approved, there remains a demand for safer and more effective adjuvants for nasal vaccines. Here, we ...

In the twentieth century, the development and delivery of vaccines as part of large, systematic immunization programs helped to address many health inequities. However, safety concerns due to ...

In a recent paper published in the Human Vaccines & Immunotherapeutics, researchers evaluated the performance and safety of nano alum adjuvant as next-generation coronavirus disease 2019 (COVID-19) ...

The role of adjuvant chemotherapy in stage II colon cancer continues to be debated. The presence of circulating tumor DNA (ctDNA) after surgery predicts very poor recurrence-free survival, whereas its ...

HHS Secretary Robert F. Kennedy Jr.'s vaccine advisors have set their sights on aluminum adjuvants in vaccines as part of their review of the U.S. pediatric vaccine schedule. While the concept of ...