Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

One can assume that the schedule changes had something to do with the records of each team. The Buccaneers and 49ers both have 3-1 records, while the Patriots and Saints are a combined 2-6. The Saints are one of just two teams that are 0-4.

NFL Week 5 announcers, channels, streaming information, times for all 14 games on the NFL Week 5 schedule this week. Who is announcing each game?

Patriots vs. Bills, Broncos vs. Eagles and Buccaneers vs. Seahawks highlight the upcoming slate. Here's the full Week 5 NFL schedule.

It's a brutal blow for the Giants to lose their star wide receiver at any time, but especially so in Week 4, as rookie quarterback Jaxson Dart makes his NFL debut. Nabers had two catches for 20 receiving yards prior to his exit, going down on a deep shot from Dart near the end zone.